Zhizhu decoction promotes gastric emptying and protects the gastric mucosa.

Wei He, Yi Zhang, Xinrui Wang, Lingling Guo, Lifeng Han, Erwei Liu, Tao Wang

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, China.

Journal of medicinal food 2013 Apr

filter terms:

The aim of this study was to evaluate the effects of the Zhizhu decoction on gastric emptying and gastric mucosal protection. The Zhizhu decoction is composed of Aurantii fructus and Atractylodes macrocephala Rhizoma. Results showed that oral administration of the Zhizhu decoction accelerated gastric emptying in mouse and protected gastric mucosa from ethanol-induced ulcers in rat. Our investigations demonstrated that the Zhizhu decoction accelerated gastric emptying, at least in part, by activating the muscarinic and 5-HT3 receptors. The gastroprotective effect is involved in its antioxidant effects and increased vascular endothelial growth factor expression.

Citation

Wei He, Yi Zhang, Xinrui Wang, Lingling Guo, Lifeng Han, Erwei Liu, Tao Wang. Zhizhu decoction promotes gastric emptying and protects the gastric mucosa. Journal of medicinal food. 2013 Apr;16(4):306-11