Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes.

Adriaan H C de Jongste, Marieke T de Graaf, Patricia D M van den Broek, Jaco Kraan, Peter A E Sillevis Smitt, Jan W Gratama

Department of Medical Oncology, Erasmus University Medical Center/Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands.

Journal of neuroimmunology 2013 May 15

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Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

Adriaan H C de Jongste, Marieke T de Graaf, Patricia D M van den Broek, Jaco Kraan, Peter A E Sillevis Smitt, Jan W Gratama. Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes. Journal of neuroimmunology. 2013 May 15;258(1-2):85-90