Complement activation by anti-GQ1b antibodies in Fisher syndrome and its variants.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. mdcyuki@nus.edu.sg

Journal of neuroimmunology 2013 May 15

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IgG anti-GQ1b antibodies are associated with Fisher syndrome (FS) as well as with its more and less extensive variants, Bickerstaff brainstem encephalitis and acute ophthalmoparesis. Passive transfer experiments provide evidence that anti-ganglioside antibodies and complement are pathogenic in the development of FS. In the current in vitro study, we could not demonstrate the association of complement activation with disease extension. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

Nobuhiro Yuki, Koichi Hirata. Complement activation by anti-GQ1b antibodies in Fisher syndrome and its variants. Journal of neuroimmunology. 2013 May 15;258(1-2):100-1