Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy.

Séverine Lorin, Marc J Tol, Chantal Bauvy, Anneke Strijland, Christian Poüs, Arthur J Verhoeven, Patrice Codogno, Alfred J Meijer

Autophagy 2013 Jun 01

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Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species.

Citation

Séverine Lorin, Marc J Tol, Chantal Bauvy, Anneke Strijland, Christian Poüs, Arthur J Verhoeven, Patrice Codogno, Alfred J Meijer. Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy. Autophagy. 2013 Jun 01;9(6):850-60