Higher-order assemblies in a new paradigm of signal transduction.

Hao Wu

Cell 2013 Apr 11

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Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction. Copyright © 2013 Elsevier Inc. All rights reserved.