Clinical review: The use of aromatase inhibitors for ovulation induction and superovulation.

Mary Ellen Pavone, Serdar E Bulun

The Journal of clinical endocrinology and metabolism 2013 May

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Anovulation is likely responsible for 20% of female infertility. Although clomiphene citrate remains the first-line therapy for ovulation induction in anovulatory patients who are not estrogen-deficient and to treat unexplained infertility, there remains a discrepancy between ovulation and conception rates with its use, attributed to its antiestrogenic effects on cervical mucus and the endometrium. Alternative agents, including aromatase inhibitors, have been used that have not been associated with these side effects. A literature search was conducted to specifically explore the use of aromatase inhibitors for ovulation induction and superovulation. Recent studies have found that aromatase inhibitors may be safe and useful agents for ovulation induction in patients with polycystic ovarian syndrome as well a treatment option for superovulation in patients with either unexplained infertility or endometriosis. Aromatase inhibitors may be an effective alternative treatment to clomiphene citrate for both ovulation induction and superovulation.

Citation

Mary Ellen Pavone, Serdar E Bulun. Clinical review: The use of aromatase inhibitors for ovulation induction and superovulation. The Journal of clinical endocrinology and metabolism. 2013 May;98(5):1838-44