Stepwise regulation of hole transport in DNA by control of triplex formation.
Ken-ichi Haruna, Haruka Iida, Sei-ichi Nishimoto, Kazuhito Tanabe
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
Bioorganic & medicinal chemistry 2013 May 15A functionality for regulating hole transport efficiency is a prerequisite for the utilization of DNA duplexes as nanodevices. Herein, we report the regulation of hole transport in anthraquinone-tethered DNA with dual triplex forming sites. Long-range photooxidation experiments showed that hole transport was effectively suppressed by the formation of triplex at low temperature, while it was recovered by dissociation to the duplex at higher temperature. Variation of temperature induced the formation and dissociation of the third strand at each triplex region individually, leading to the stepwise regulation of hole transport in DNA. Copyright © 2013 Elsevier Ltd. All rights reserved.
Citation
Ken-ichi Haruna, Haruka Iida, Sei-ichi Nishimoto, Kazuhito Tanabe. Stepwise regulation of hole transport in DNA by control of triplex formation. Bioorganic & medicinal chemistry. 2013 May 15;21(10):2682-6
PMID: 23587656
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