Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

T cells function locally. Accordingly, T cells' recognition of antigen, their subsequent activation and differentiation, and their role in the processes of infection control, tumour eradication, autoimmunity, allergy and alloreactivity are intrinsically coupled with migration. Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current paradigms. Here, we review classic and emerging concepts, highlight the challenge of integrating new observations with existing T cell classification schemes and summarize the heuristic framework provided by viewing T cell differentiation and function first through the prism of migration.

Citation

David Masopust, Jason M Schenkel. The integration of T cell migration, differentiation and function. Nature reviews. Immunology. 2013 May;13(5):309-20

Expand section icon Mesh Tags


PMID: 23598650

View Full Text