A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets.

An unknown impurity detected in small amounts during the heat treatment of artesunate-amodiaquine bilayer tablets was purified by semipreparative HPLC and identified by MS and NMR as the tetrahydrofuranyl acetate-rearranged derivative of anhydrodihydroartemisinin. When anhydrodihydroartemisinin was treated with a Fe(II) salt in acetonitrile-water solution, the same product was generated, together with an isomeric 2-deoxy-4α-hydroxy-anhydrodihydroartemisinin derivative, as expected from the usual homolytic radical opening of the endoperoxide bond previously described for other artemisinin derivatives. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

Cedric Charrier, Gildas Bertho, Olivier Petigny, Philippe Moneton, Robert Azerad. A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets. Journal of pharmaceutical and biomedical analysis. 2013 Jul-Aug;81-82:20-6

PMID: 23603276

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