Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells.

We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

Masataka Uchida, Eri Oyanagi, Motohiko Miyachi, Akira Yamauchi, Hiromi Yano. Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells. Journal of immunological methods. 2013 Jul 31;393(1-2):61-9

PMID: 23603617

search → result