Paraneoplastic disorders of the peripheral nervous system.

Jean-Christophe Antoine, Jean-Philippe Camdessanché

Department of Neurology, University Hospital of Saint-Étienne, Saint-Étienne, France. j.christophe.antoine@chu-st-etienne.fr

Presse médicale (Paris, France : 1983) 2013 Jun

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Paraneoplastic neurological syndromes are rare but can affect any part of the peripheral nervous system (PNS) including motor neurons, sensory ganglia, nerve roots, plexuses, cranial and peripheral nerves, and neuromuscular junctions. The type of cancer, lymphoma or solid tumour, is a determinant factor of the underlying mechanism. With solid tumour, antibodies directed to intracellular (anti-Hu or anti-CV2/CRMP5 antibodies) or surface antigens (anti-VGCC,or LGI1 and Caspr2 antibodies) have been identified while with lymphoma, the neuropathy is usually linked to a monoclonal gammopathy. This review discusses the different etiologies and mechanisms of paraneoplastic disorders of the PNS in patients emphasising their evaluation, diagnosis and treatment. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Citation

Jean-Christophe Antoine, Jean-Philippe Camdessanché. Paraneoplastic disorders of the peripheral nervous system. Presse médicale (Paris, France : 1983). 2013 Jun;42(6 Pt 2):e235-44