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Anticonvulsant Hypersensitivity Syndrome (AHS) is a rare complication of common drugs used today. It is unusual in that it occurs later than most other drug reactions, about two to six weeks after initiation of the offending agent. It also has a hereditary background unlike most other drug reactions. This reaction is caused by the aromatic amines and causes hepatitis, skin rash, fever, and other systemic organ involvement can occur. The reaction is rare but often fatal, thus the observer should be acutely aware of this in the months following initiation of the agents.


Bradley R Keel, Catherine L Payne. Anticonvulsant hypersensitivity syndrome (AHS): a case report. Tennessee medicine : journal of the Tennessee Medical Association. 2013 Apr;106(4):35-6, 38

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PMID: 23617037

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