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Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease. Copyright © 2013 Institut Pasteur. All rights reserved.


Alexander D Radian, Lucia de Almeida, Andrea Dorfleutner, Christian Stehlik. NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease. Microbes and infection / Institut Pasteur. 2013 Jul-Aug;15(8-9):630-9

PMID: 23618810

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