A novel acetylcholine bioensor and its electrochemical behavior.

Wei Wang, Yan Deng, Song Li, Hongna Liu, Zhuoxuan Lu, Liming Zhang, Lin Lin, Lijian Xu

Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China.

Journal of biomedical nanotechnology 2013 Apr

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A novel type of acetylcholine electrochemical biosensor was successfully fabricated by dropping beta-cyclodextrin solution, acetylcholinesterase solution and Nafion-methanol solution to the homemade nano-porous pseudo carbon paste electrode (nano-PPCPE) as working electrode, and then the electrochemical behavior of the as-prepared biosensor was studied through the acetylthiocholine iodide (ATChI). It was shown that the modified nano-PPCPE displays a high selectivity and sensitivity. The acetylcholine biosensor showed the linear range from 5 x 10(-6) M to 2 x 10(-4) M with the detection limit of 1.5 x 10(-7) M.

Citation

Wei Wang, Yan Deng, Song Li, Hongna Liu, Zhuoxuan Lu, Liming Zhang, Lin Lin, Lijian Xu. A novel acetylcholine bioensor and its electrochemical behavior. Journal of biomedical nanotechnology. 2013 Apr;9(4):736-40