Correlation Engine 2.0
Clear Search sequence regions

Despite increasing evidence highlighting the role of NPY in the modulation of inflammatory reaction, surprisingly little is known about the direct effects of NPY on the release of proinflammatory mediators. In the present work, we have evaluated the effects of NPY on the release of TNF-α, IL-1β, IL-6 and HMGB1 mediators in peritoneal macrophages. Our results demonstrate for the first time that NPY can directly induce active HMGB1 release and cytoplasmic translocation, while the production of TNF-α, IL-1β and IL-6 is not affected. PKC and ERK pathway inhibitors can abolish the promotive effect of NPY on HMGB1 secretion. Thus, our results indicate that NPY might impact on the innate immune system by directly potentiating the HMGB1 release from the macrophage. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.


Jiang-Rui Zhou, Lu-Ding Zhang, Hua-Feng Wei, Xia Wang, Hai-Lai Ni, Fu Yang, Ting Zhang, Chun-Lei Jiang. Neuropeptide Y induces secretion of high-mobility group box 1 protein in mouse macrophage via PKC/ERK dependent pathway. Journal of neuroimmunology. 2013 Jul 15;260(1-2):55-9

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 23623189

View Full Text