Sarah Al Naieb, Christoph M Happel, T Mesud Yelbuz
Department of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Sarah.Naieb@stud.mh-hannover.de
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2013 JulVarious model organisms such as mouse, xenopus, or zebrafish embryos have been studied in the past to gain insight into the complex processes driving normal and abnormal development of the vertebrate heart. Despite the fact that the chicken embryo has been a favored classic model system used by embryologists and cardiovascular scientists for centuries to illustrate the principles of basic vertebrate embryology and cardiovascular development, so far, no one has provided a thorough documentation of heart development in this model from early visual stages to the stage of a completely formed heart with (a) images and (b) video recordings of beating hearts. However, in vivo documentation of heart development stages is indispensable because the initially tubular embryonic heart not only undergoes dramatic morphological changes, but also intriguing functional changes during cardiogenesis, which, only if they follow and remain within the normal developmental pathway, lead to the establishment of the normal four-chambered heart. In this work we present the first reference catalogue of cardiac development in vivo with (1) 25 plates of high resolution colour images in different views from Hamburger-Hamilton (HH)-stage 12 (day 2, relatively straight heart tube, early myocardial contractions) through HH-stage 35 (day 9, four-chambered heart) in end-diastole and end-systole, including a plate with an overview of all these stages; (2) collection of 82 video recordings of beating hearts in different views corresponding to the stages shown in the plates. Copyright © 2012 Elsevier GmbH. All rights reserved.
Sarah Al Naieb, Christoph M Happel, T Mesud Yelbuz. A detailed atlas of chick heart development in vivo. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2013 Jul;195(4):324-41
PMID: 23623231
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