Correlation Engine 2.0
Clear Search sequence regions

Size and folding of the cerebral cortex increased massively during mammalian evolution leading to the current diversity of brain morphologies. Various subtypes of neural stem and progenitor cells have been proposed to contribute differently in regulating thickness or folding of the cerebral cortex during development, but their specific roles have not been demonstrated. We report that the controlled expansion of unipotent basal progenitors in mouse embryos led to megalencephaly, with increased surface area of the cerebral cortex, but not to cortical folding. In contrast, expansion of multipotent basal progenitors in the naturally gyrencephalic ferret was sufficient to drive the formation of additional folds and fissures. In both models, changes occurred while preserving a structurally normal, six-layered cortex. Our results are the first experimental demonstration of specific and distinct roles for basal progenitor subtypes in regulating cerebral cortex size and folding during development underlying the superior intellectual capability acquired by higher mammals during evolution.


Miki Nonaka-Kinoshita, Isabel Reillo, Benedetta Artegiani, Maria Ángeles Martínez-Martínez, Mark Nelson, Víctor Borrell, Federico Calegari. Regulation of cerebral cortex size and folding by expansion of basal progenitors. The EMBO journal. 2013 Jul 3;32(13):1817-28

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 23624932

View Full Text