Kdo2-lipid A modification in gram-negative bacteria--a review].

Xiaoyuan Wang

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. xiaoyuanwang@hotmail.com

Wei sheng wu xue bao = Acta microbiologica Sinica 2013 Feb 4

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In most Gram-negative bacteria, the Kdo2-lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane. Diverse covalent modifications of Kdo2-lipid A may occur in bacteria to survive different environmental conditions. Kdo2-lipid A is usually synthesized on the cytoplasmic surface of the inner membrane. After the core oligosaccharide is attached to Kdo2-lipid A, the molecule is flipped to the outer surface of the inner membrane, where the O-antigen repeats are attached to form lipopolysaccharide. Kdo2-lipid A could activate the innate immune system through TLR4. Therefore, researches on the structure modification of Kdo2-lipid A would be useful for developing new vaccines and adjuvants.

Citation

Xiaoyuan Wang. Kdo2-lipid A modification in gram-negative bacteria--a review]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2013 Feb 4;53(2):111-7