Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate].

M A Iudin, S V Chepur, V N Bykov, A F Kurpiakova, S N Subbotina, A S Nikiforov, I M Ivanov

Eksperimental'naia i klinicheskaia farmakologiia 2013

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The effect of memantine administration has been studied on the model of mice poisoning with an anticholinesterase compound. It is established that the memantine action is due to its influence on the cholinesterase activity in the brain, blood plasma, and erythrocytes in addition to its NMDA-blocking action. Memantine promotes oxime-induced erythrocyte enzyme reactivation on the model of mice poisoning with anticholinesterase compound (0.8 LD50).

Citation

M A Iudin, S V Chepur, V N Bykov, A F Kurpiakova, S N Subbotina, A S Nikiforov, I M Ivanov. Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate]. Eksperimental'naia i klinicheskaia farmakologiia. 2013;76(2):3-5