Coenzyme Q10 single intravenous infusion protects rat myocardium against subsequent ischemia/reperfusion].

A V Ivanov, E A Gorodetskaia, E I Kalenikova, O S Medvedev

Eksperimental'naia i klinicheskaia farmakologiia 2013

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Cardioprotective effects of coenzyme Q10 (CoQ10) injected intravenously 30 min before coronary artery occlusion were assessed on the model of myocardial ischemia/reperfusion in Wistar rats. Rats treated with CoQ10 after 30 min of ischemia and 120 min of reperfusion exhibited smaller (by 35%, p < 0.01) size of irreversibly damaged myocardium, shorter duration and decreased number of arrhythmias during reperfusion, and increased content of myocardial CoQ10 (by 210%, p < 0.01) as compared to saline-treated rats. Increased CoQ10 levels in myocardium were accompanied by smaller size of damaged myocardium (r = -0.77, p = 0.0002). Thus, there is evidence of the cardioprotective effect of CoQ10 injected intravenously before myocardial ischemia/reperfusion.

Citation

A V Ivanov, E A Gorodetskaia, E I Kalenikova, O S Medvedev. Coenzyme Q10 single intravenous infusion protects rat myocardium against subsequent ischemia/reperfusion]. Eksperimental'naia i klinicheskaia farmakologiia. 2013;76(2):6-8