Changes in CO2 concentration increase the invasive ability of colon cancer cells.

Shinsuke Obata, Takanori Goi, Toshiyuki Nakazawa, Youhei Kimura, Kanji Katayama, Akio Yamaguchi

First Department of Surgery, University of Fukui, 23-3, Eiheiji-cho, Yoshida-gun, Fukui, Japan.

Anticancer research 2013 May

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We studied the effects of CO(2) concentration changes on the invasive ability of colon cancer cells. Colon cancer cell lines and human samples derived from a peritoneal metastasis were incubated in a hypercapnic environment, followed by incubation in 5% CO(2). The invasive ability of colon cancer cells incubated with CO(2) were analyzed using an invasion assay system. In comparison with the colon cancer cell lines incubated in 5% CO(2) only, the invasive ability of cells increased in all the colon cancer cell lines subjected to incubation in 20% CO(2) followed by incubation in 5% CO(2), with a concomitant increase in the mRNA expressions of matrix metalloproteinase-2 (MMP2) and MMP9. The invasive capability of peritoneal metastatic cells in the human-derived specimen also increased on CO(2) concentration changes. CO(2) concentration changes enhanced the invasive capacity of colon cancer cells.

Citation

Shinsuke Obata, Takanori Goi, Toshiyuki Nakazawa, Youhei Kimura, Kanji Katayama, Akio Yamaguchi. Changes in CO2 concentration increase the invasive ability of colon cancer cells. Anticancer research. 2013 May;33(5):1881-5