Improvement of the oral bioavailability of coenzyme Q10 with lecithin nanocapsules.

Huafeng Zhou, Jing Zhang, Yingfang Long, Guoqing Liu, Mingxing Duan, Qiang Xia

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

Journal of nanoscience and nanotechnology 2013 Jan

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Coenzyme Q10-loaded lecithin nanocapsules (CoQ10-LNCs), composed of a CoQ10/lecithin/ GTCC/glycerol aqueous solution, were prepared by high-pressure homogenization. The zeta potential of the CoQ10-LNCs above -60 mV was determined on a Malvern Zetasize 2000 (Malvern Instruments, UK). The spherical shape of the CoQ10-LNCs was observed by using freeze-fracture transmission electron microscopy (FF-TEM), and the particle size was found to be below 100 nm. The supercooled state of the CoQ10-LNCs was observed by differential scanning calorimetry (DSC). In an oral bioavailability study, the CoQ10 plasma level after administering CoQ10-LNCs was higher than that after administering a CoQ10 tablet over 24 hours, and the relative bioavailability of CoQ10 was improved to 176.6% in mice. Based on the above results, the LNC delivery system might be a potential vehicle for improving the oral bioavailability of CoQ10.

Citation

Huafeng Zhou, Jing Zhang, Yingfang Long, Guoqing Liu, Mingxing Duan, Qiang Xia. Improvement of the oral bioavailability of coenzyme Q10 with lecithin nanocapsules. Journal of nanoscience and nanotechnology. 2013 Jan;13(1):706-10