Population genetics of Haemophilus influenzae serotype a in three Canadian provinces.

Raymond S W Tsang, Michelle Shuel, John Wylie, Brigitte Lefebvre, Linda Hoang, Dennis K S Law

Vaccine Preventable Bacterial Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada. raymond.tsang@phac-aspc.gc.ca

Canadian journal of microbiology 2013 May

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Haemophilus influenzae serotype a (Hia) is an important pathogen since the introduction of vaccines for control of disease due to serotype b strains. Using a sodC-based polymerase chain reaction, Hia can be divided into 2 phylogenetic divisions, each with their own unique multilocus sequence types. Most Canadian Hia belongs to clonal division I and the ST-23 clonal complex. The recently described hypervirulent clone of ST-4 was found in a single Canadian isolate. Therefore, surveillance of invasive H. influenzae disease should include serotyping to detect Hia and multilocus sequence typing to detect hypervirulent clones.

Citation

Raymond S W Tsang, Michelle Shuel, John Wylie, Brigitte Lefebvre, Linda Hoang, Dennis K S Law. Population genetics of Haemophilus influenzae serotype a in three Canadian provinces. Canadian journal of microbiology. 2013 May;59(5):362-4