Role of spatio-temporal non uniformities in blood coagulation regulation].

A M Shibeko, F I Ataullakhanov

Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 2013 Jan

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This paper reviews some contemporary researches of thrombosis and hemostasis process that consider its spatio-temporal dynamics. Among them, there are platelet distribution in the blood vessel and the dependence of the platelet plug growth on the hematocrit level; influence of the tissue factor density on the blood coagulation onset and on the efficacy of some drugs, designed for the hemostasis improvement; regulation of blood coagulation by the flow rate. Mechanisms controlling the mentioned processes are described. Clinical significance and novel diagnostic and therapeutic approaches are discussed from the position of the spatio-temporal non uniformities of thrombosis and hemosatsis.

Citation

A M Shibeko, F I Ataullakhanov. Role of spatio-temporal non uniformities in blood coagulation regulation]. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. 2013 Jan;99(1):33-43