Barrier elements of chromatin domains and nuclear envelope].

A N Shabarina, M V Glazkov

Koltsov Institute of Developmental Biology, Moscow, Russia

Genetika 2013 Jan

filter terms:

The results of investigating the functions of different barrier elements, including insulators and MARs/SARs and the models of their effect, are described. The functions of neDNA (DNA from the nuclear envelopes) as a barrier element that protects the transgene from position-effect variegation and its interaction with insulators are discussed. The possible mechanisms of the functioning of structural and functional units of eukaryotic chromosomes of different species are suggested.