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The results of investigating the functions of different barrier elements, including insulators and MARs/SARs and the models of their effect, are described. The functions of neDNA (DNA from the nuclear envelopes) as a barrier element that protects the transgene from position-effect variegation and its interaction with insulators are discussed. The possible mechanisms of the functioning of structural and functional units of eukaryotic chromosomes of different species are suggested.


A N Shabarina, M V Glazkov. Barrier elements of chromatin domains and nuclear envelope]. Genetika. 2013 Jan;49(1):30-6

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PMID: 23662422

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