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The results of macrophage metabolism studies at their infection by viruses differing in the level of virulence are presented. With the purpose of optimizing the estimation of viral cytopathogenic effects on macrophages, an index of cell reactions, which allows one to reveal the degree of virus influence in standard units, is offered. Generally, the application of high-sensitivity methods for functional activity determination and identification of the correlative communication between its changes and morphological features of cells can be prescribed to objective identification methods of not only viral reproduction, but also differentiation of types and the degree of their cytopathogenic effects.


N G Plekhanova, L M Somova, N V Krylova, G N Leonova, I N Liapun, I S Smirnov. Biochemical markers of virus cytopathogenicity in macrophages]. Prikladnaia biokhimiia i mikrobiologiia. 2013 Jan-Feb;49(1):72-81

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PMID: 23662454

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