The expanding family of FERM proteins.

Susana Moleirinho, Andrew Tilston-Lunel, Liselotte Angus, Frank Gunn-Moore, Paul A Reynolds

Medical and Biological Sciences Building, School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK.

The Biochemical journal 2013 Jun 1

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Our understanding of the FERM (4.1/ezrin/radixin/moesin) protein family has been rapidly expanding in the last few years, with the result that many new physiological functions have been ascribed to these biochemically unique proteins. In the present review, we will discuss a number of new FRMD (FERM domain)-containing proteins that were initially discovered from genome sequencing but are now being established through biochemical and genetic studies to be involved both in normal cellular processes, but are also associated with a variety of human diseases.

Citation

Susana Moleirinho, Andrew Tilston-Lunel, Liselotte Angus, Frank Gunn-Moore, Paul A Reynolds. The expanding family of FERM proteins. The Biochemical journal. 2013 Jun 1;452(2):183-93