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CD147 or EMMPRIN belongs to the immunoglobulin superfamily of membrane receptors and is expressed in epithelial cells, cancer cells and T cells of the immune system. In T cells CD147 functions as a receptor for soluble cyclophilins and is involved in chemotaxis. We recently reported its expression to high levels and association with suppressive function in regulatory T cells. Here, we discuss its potential application as a marker of activated regulatory T cells. Copyright © 2013 Elsevier Inc. All rights reserved.

Citation

Johannes Landskron, Kjetil Taskén. CD147 in regulatory T cells. Cellular immunology. 2013 Mar;282(1):17-20

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PMID: 23665204

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