CD147 in regulatory T cells.

Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, P.O. Box 1125 Blindern, N-0318 Oslo, Norway.

Cellular immunology 2013 Mar

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CD147 or EMMPRIN belongs to the immunoglobulin superfamily of membrane receptors and is expressed in epithelial cells, cancer cells and T cells of the immune system. In T cells CD147 functions as a receptor for soluble cyclophilins and is involved in chemotaxis. We recently reported its expression to high levels and association with suppressive function in regulatory T cells. Here, we discuss its potential application as a marker of activated regulatory T cells. Copyright © 2013 Elsevier Inc. All rights reserved.