Optimizing the relaxivity of Gd(III) complexes appended to InP/ZnS quantum dots by linker tuning.

Graeme J Stasiuk, Sudarsan Tamang, Daniel Imbert, Christelle Gateau, Peter Reiss, Pascal Fries, Marinella Mazzanti

CEA, INAC, SCIB, Laboratoire de Reconnaissance Ionique et Chimie de Coordination, CEA-Grenoble, UJF, LCIB, UMR-E 3 CEA-UJF, 38054 Grenoble Cedex 9, France.

Dalton transactions (Cambridge, England : 2003) 2013 Jun 21

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Three bimodal MRI/optical nanosized contrast agents with high per-nanoparticle relaxivity (up to 2523 mM(-1) s(-1) at 35 MHz and 932 mM(-1) s(-1) at 200 MHz) have been prepared connecting up to 115 tris-aqua Gd(III) complexes to fluorescent non-toxic InP/ZnS quantum dots. The structure of the linker has an important effect on the relaxivity of the final multimeric contrast agent.

Citation

Graeme J Stasiuk, Sudarsan Tamang, Daniel Imbert, Christelle Gateau, Peter Reiss, Pascal Fries, Marinella Mazzanti. Optimizing the relaxivity of Gd(III) complexes appended to InP/ZnS quantum dots by linker tuning. Dalton transactions (Cambridge, England : 2003). 2013 Jun 21;42(23):8197-200

PMID: 23665764

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