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In the present article the features of the functional activity of the anterior cingulate cortex (ACC), a key element of neuroanatomical brain system of an error detection, in drug-resistant forms of obsessive-compulsive disorder (OCD) are discussed on a basis of both original and literature data. Available data indicate the presence of functional deficit in the ACC during OCD. This allows to suggest that functions of the ACC in OCD patient are partially redistributed between other brain areas. Thus in contrast to the previously accepted notion, the ACC as the target ofstereotactic surgery for OCD is pathologically altered brain region. Probably this is the reason why stereotactic destruction of ACC does not lead to significant changes in the patient's psyche. The essence of the pathological reorganisation of the functional activity of the brain in OCD remains unclear and requires further investigation.


M V Kireev, N S Medvedev, A D Korotkov, Iu I Poliakov, A D Anichkov, S V Medvedev. Pathology of the anterior cingulate cortex in obsessive compulsive disorder]. Fiziologiia cheloveka. 2013 Jan-Feb;39(1):67-70

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PMID: 23668073

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