Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia.

Amalia Biron Research Institute of Thrombosis and Haemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel. ophiras@sheba.health.gov.il

British journal of haematology 2013 Aug

filter terms:

Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a devastating bleeding disorder in the fetus or neonate caused by transplacental transport of maternal alloantibodies to paternal-derived antigen on fetal platelets. In Caucasians, up to 80% of FNAIT cases result from maternal immunization to human platelet antigen (HPA)-1a. New methods have developed facilitating detection of common and private antibodies against HPAs triggering FNAIT. Understanding the pathogenesis of FNAIT made it possible to develop a novel strategy to treat this disorder. To date, recombinant monoclonal antibodies directed against the β3 integrin and Fc receptors have been tested in a mouse model of FNAIT, and seem to be promising. Whether those novel treatments will eventually replace the conventional high dose immunoglobulin G in women with FNAIT is yet unknown. © 2013 John Wiley & Sons Ltd.

Citation

Ophira Salomon, Nurit Rosenberg. Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia. British journal of haematology. 2013 Aug;162(3):304-12