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We review the concept of superresolution optical fluctuation imaging (SOFI), discuss its attributes and trade-offs (in comparison with other superresolution methods), and present superresolved images taken on samples stained with quantum dots, organic dyes, and plasmonic metal nanoparticles. We also discuss the prospects of SOFI for live cell superresolution imaging and for imaging with other (non-fluorescent) contrasts.


Thomas Dertinger, Alessia Pallaoro, Gary Braun, Sonny Ly, Ted A Laurence, Shimon Weiss. Advances in superresolution optical fluctuation imaging (SOFI). Quarterly reviews of biophysics. 2013 May;46(2):210-21

PMID: 23672771

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