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Frequency-domain optical coherence tomography (FD-OCT) is a novel technology which provides high-resolution cross-sectional images of coronary arteries. The aim of this study was to evaluate the inter-scan reproducibility of geometric FD-OCT measurements in the clinical setting. We examined 20 coronary lesions using FD-OCT. Following the FD-OCT image acquisition (1st pullback), and after the disengagement and re-engagement of the guiding catheter, an additional acquisition (2nd pullback) was performed using a new FD-OCT catheter. There was excellent correlation for minimum lumen area (r = 0.99, P < 0.001), lesion length (r = 0.99, P < 0.001) and lumen volume (r = 0.99, P < 0.001) between the 1st pullback and the 2nd pullback. The Bland-Altman test demonstrated good agreement between the 1st pullback and the 2nd pullback: the mean difference for minimum lumen area, lesion length, and lumen volume was 0.05 mm(2), 0.03 mm, and 0.70 mm(3), respectively; and the lower and upper limit of agreement for minimum lumen area, lesion length, and lumen volume was -0.58 and 0.48, -0.36 and 0.42, and -13.4 and 12.1, respectively. FD-OCT showed an excellent inter-scan reproducibility for the geometric coronary artery measurements. Our findings emphasize the value of FD-OCT as a tool for clinical longitudinal studies of coronary artery disease.


Makoto Orii, Takashi Kubo, Atsushi Tanaka, Hironori Kitabata, Yasushi Ino, Yasutsugu Shiono, Kunihiro Shimamura, Hiroshi Aoki, Shingo Ohta, Yuichi Ozaki, Kohei Ishibashi, Takashi Yamano, Takashi Tanimoto, Tomoyuki Yamaguchi, Kumiko Hirata, Toshio Imanishi, Takashi Akasaka. Inter-scan reproducibility of geometric coronary artery measurements using frequency-domain optical coherence tomography. International heart journal. 2013;54(2):64-7

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PMID: 23676364

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