Takatsugu Yamamoto, Koichiro Abe, Yasushi Kuyama
Department of Internal Medicine, Teikyo University.
Nihon rinsho. Japanese journal of clinical medicine 2013 AprSelective serotonin reuptake inhibitors (SSRI) are widely used antidepressants characterized by less-frequent adverse effects compared with classical anti-depressive agents. On the other hand, SSRI can cause hemorrhagic events more due to impaired platelet aggregation induced by a depletion of serotonin in the peripheral platelet. Epidemiological studies have indicated that patients taking SSRI are predisposed to gastrointestinal hemorrhage, especially in case that nonsteroidal anti-inflammatory drugs are prescribed concomitantly. Here we describe a risk of the gastrointestinal hemorrhage in patients taking SSRI.
Takatsugu Yamamoto, Koichiro Abe, Yasushi Kuyama. Selective serotonin reuptake inhibitor and gastrointestinal hemorrhage]. Nihon rinsho. Japanese journal of clinical medicine. 2013 Apr;71(4):751-6
PMID: 23678611
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