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Selective serotonin reuptake inhibitors (SSRI) are widely used antidepressants characterized by less-frequent adverse effects compared with classical anti-depressive agents. On the other hand, SSRI can cause hemorrhagic events more due to impaired platelet aggregation induced by a depletion of serotonin in the peripheral platelet. Epidemiological studies have indicated that patients taking SSRI are predisposed to gastrointestinal hemorrhage, especially in case that nonsteroidal anti-inflammatory drugs are prescribed concomitantly. Here we describe a risk of the gastrointestinal hemorrhage in patients taking SSRI.


Takatsugu Yamamoto, Koichiro Abe, Yasushi Kuyama. Selective serotonin reuptake inhibitor and gastrointestinal hemorrhage]. Nihon rinsho. Japanese journal of clinical medicine. 2013 Apr;71(4):751-6

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PMID: 23678611

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