Antifouling indole alkaloids from two marine derived fungi.

Fei He, Zhuang Han, Jiang Peng, Pei-Yuan Qian, Shu-Hua Qi

Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, China.

Natural product communications 2013 Mar

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In order to find non-toxic antifouling natural products from marine microorganisms, the chemical constituents of two marine derived fungi Penicillium sp. and Aspergillus sydowii have been investigated under bio-guided fractionation. A new indolyl diketopiperazine compound, penilloid A (1), together with 15 known ones were isolated from these two strains. The structure of 1 was elucidated on the basis of NMR and mass spectra. Some alkaloids showed significant antifouling and antibacterial activities. The results indicate that indole alkaloids could be a potential antifouling agent resource.

Citation

Fei He, Zhuang Han, Jiang Peng, Pei-Yuan Qian, Shu-Hua Qi. Antifouling indole alkaloids from two marine derived fungi. Natural product communications. 2013 Mar;8(3):329-32