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The biotransformation of osthole (1) by Alternaria longipes was carried out, and five transformed products were obtained in the present research work. Based on their extensive spectral data, the structures of these metabolites were characterized as 4'-hydroxyl-osthole (2), 4'-hydroxyl-2',3'-dihydroosthole (3), 2',3'-dihydroxylosthole (4), osthole-4'-oic acid methyl ester (5), and osthole-4'-oic acid glucuron-1-yl ester (6), respectively. Among them, products 5 and 6 were new compounds.


Xiu-Lan Xin, Pei Pei Dong, Gang Wang, Rong-Gang Xi, Dan Liu, Zhi-Ming Wu, Xian-Ce Sun, Rong Lan, Xiao-Bo Wang. Biotransformation of osthole by Alternaria longipes. Journal of Asian natural products research. 2013 Jul;15(7):717-22

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PMID: 23679093

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