Exposure to low dose ionising radiation: Molecular and clinical consequences.
Lynn M Martin, Brian Marples, Thomas H Lynch, Donal Hollywood, Laure Marignol
Urologic and Radiation Oncology, Applied Radiation Therapy Trinity and Prostate Molecular Oncology Research Group, Discipline of Radiation Therapy and Institute of Molecular Medicine, Trinity College Dublin, Ireland.
Cancer letters 2013 Sep 28This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Citation
Lynn M Martin, Brian Marples, Thomas H Lynch, Donal Hollywood, Laure Marignol. Exposure to low dose ionising radiation: Molecular and clinical consequences. Cancer letters. 2013 Sep 28;338(2):209-18
PMID: 23693079
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