Comparison of the clotting factor activity and thawing time in different thawing procedures of the fresh frozen plasma].

Yoshinori Tanigawa, Manabu Tanaka, Yoshinori Maeda, Akira Nakagawachi, Satsuki Hamada, Yoshiro Sakaguchi

Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Saga University, Saga 849-850.

Masui. The Japanese journal of anesthesiology 2013 Apr

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Fresh frozen plasma (FFP) should be thawed in a water bath at 30-37 degrees C. Suitable temperature, the prevention for bacterial contamination, and the efficiency of the process are necessary for a thawing procedure. In this study, we compared the clotting factor activity and thawing time in different thawing procedures; a water bath, the thermostatic thawing chamber (FP-40, Hokuyo ; Kawasumi, Japan), and the microwave system (Transfusio-therm 2000 AMCO; Zeipel, Germany). Thawing time and the clotting factor activity (prothrombin time: PT, prothrombin time-international normalized ratio: PT-INR, activated partial thromboplastin time: APTT, fibrinogen, andfactors V) of thawed FFP-5 units were measured. Thawing time using Transfusio-therm 2000 was 11.4 minutes, which was faster than that using the water bath and FP-40 of about 39.5 and 27.3 minutes, respectively (P<0.01). There were no differences between the three methods in terms of the clotting factors. The microwave system is useful in shortening the time safety, and maintaining the clotting factor activity in thawed FFP

Citation

Yoshinori Tanigawa, Manabu Tanaka, Yoshinori Maeda, Akira Nakagawachi, Satsuki Hamada, Yoshiro Sakaguchi. Comparison of the clotting factor activity and thawing time in different thawing procedures of the fresh frozen plasma]. Masui. The Japanese journal of anesthesiology. 2013 Apr;62(4):495-9