EDTA-dependent pseudothrombocytopenia complicated by eosinophilic pneumonia.

EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is a phenomenon that occurs in vitro when EDTA reacts with harvested blood. EDTA-dependent pseudothrombocytopenia usually does not indicate thrombocytopenia in vivo. Here, we report the first case of EDTA-PTCP complicated by eosinophilic pneumonia. A 70-year-old man with rectal cancer was admitted to the hospital for a liver abscess and rectal cancer. At the time of admission, his platelet count was 20,000/μL, but a peripheral blood smear showed platelet aggregation and the platelet count for a kanamycin-added EDTA blood sample was 180,000/μL. The patient's respiratory status worsened after treatment for the liver abscess and rectal cancer. The patient's bronchoalveolar lavage contained 45% eosinophils, and a diagnosis of acute eosinophilic pneumonia was made. In recent studies, the occurrence of eosinophilic disease has been shown in idiopathic thrombocytopenic purpura. EDTA-dependent pseudothrombocytopenia is an in vitro phenomenon, although platelet activation that results in eosinophil invasion may occur in severe cases.

Citation

Naoko Ohashi, Kensuke Nakamura, Ryota Inokuchi, Hajime Sato, Kurato Tokunaga, Tatsuma Fukuda, Susumu Nakajima, Naoki Yahagi. EDTA-dependent pseudothrombocytopenia complicated by eosinophilic pneumonia. The American journal of emergency medicine. 2013 Jul;31(7):1157.e5-7

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PMID: 23702069

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