Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder.

Gender Identity Disorder Program, Hospital de Clinicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, INCT for Translational Medicine, Hospital de Clinicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Journal of psychiatric research 2013 Oct

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Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis of psychiatric disordersand is related to traumatic life events. To examine serum BDNF levels, we compared one group of DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF levels were significantly decreased in GID patients (p = 0.013). This data support the hypothesis that the reduction found in serum BDNF levels in GID patients may be related to the psychological abuse that transsexuals are exposed during their life. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Anna-Martha V Fontanari, Tahiana Andreazza, Angelo B Costa, Jaqueline Salvador, Walter J Koff, Bianca Aguiar, Pamela Ferrari, Raffael Massuda, Mariana Pedrini, Esalba Silveira, Paulo S Belmonte-de-Abreu, Clarissa S Gama, Marcia Kauer-Sant'anna, Flavio Kapczinski, Maria Ines R Lobato. Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. Journal of psychiatric research. 2013 Oct;47(10):1546-8

PMID: 23702250

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