Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis of psychiatric disordersand is related to traumatic life events. To examine serum BDNF levels, we compared one group of DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF levels were significantly decreased in GID patients (p = 0.013). This data support the hypothesis that the reduction found in serum BDNF levels in GID patients may be related to the psychological abuse that transsexuals are exposed during their life. Copyright © 2013 Elsevier Ltd. All rights reserved.


Anna-Martha V Fontanari, Tahiana Andreazza, Angelo B Costa, Jaqueline Salvador, Walter J Koff, Bianca Aguiar, Pamela Ferrari, Raffael Massuda, Mariana Pedrini, Esalba Silveira, Paulo S Belmonte-de-Abreu, Clarissa S Gama, Marcia Kauer-Sant'anna, Flavio Kapczinski, Maria Ines R Lobato. Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. Journal of psychiatric research. 2013 Oct;47(10):1546-8

PMID: 23702250

View Full Text