Immunology of age-related macular degeneration.

Jayakrishna Ambati, John P Atkinson, Bradley D Gelfand

Nature reviews. Immunology 2013 Jun

filter terms:

Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

Citation

Jayakrishna Ambati, John P Atkinson, Bradley D Gelfand. Immunology of age-related macular degeneration. Nature reviews. Immunology. 2013 Jun;13(6):438-51