Mass spectrum characterization of five valepotriates by electrospray ionization tandem mass spectrometry].

Chun-Guo Wang, Yong Liu, Jin-Li Shi, Yao Xiao, Shu-Ning Shi, Wen-Hui Hou, Zi-Jian Wang

Beijing University of Chinese Medicine, Beijing 100029, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2013 Feb

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To discuss mass spectrum characterization of five valepotriates including 'monoene' type (didrovaltrate), 'diene' type (valtrate, acevaltrate) and 'four-olefinic' type (baldrinal and homobaldrinal) by electrospray ionization tandem mass spectrometry (ESI-MS(n)). This study was carried out on the basis of electrospray ionization tandem mass spectrometric method and analysis of multistage fragments. The fragmentation patterns and structural assignment of 'monoene' type, 'diene' type and 'four-olefinic' type valepotriates in ESI-MSn under positive mode were summarized. The compounds have a strong pyrolysis rules and it can provide reference date for valepotriates in rapid structural identification, quantitative analysis and pharmacokinetic study.

Citation

Chun-Guo Wang, Yong Liu, Jin-Li Shi, Yao Xiao, Shu-Ning Shi, Wen-Hui Hou, Zi-Jian Wang. Mass spectrum characterization of five valepotriates by electrospray ionization tandem mass spectrometry]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Feb;38(4):578-84