Systemic and neurological uses of immunosuppressive agents].

C Schnider, J D Seebach, C Ribi, F Spertini

Faculté de médecine, Université de Lausanne, Lausanne. caroline.schnider@unil.ch

Revue médicale suisse 2013 May 1

filter terms:

Involvement of the central or peripheral nervous system, frequently present in systemic inflammatory immune disorders, has to be considered a severe threat and requires aggressive immunosuppressive treatment to achieve rapid remission. This is usually obtained with high-dose systemic corticosteroids combined with cyclophosphamide. Once remission is obtained, immunosuppressive agents with a more favorable safety profile are needed to exert a corticosteroid-sparing effect and minimize adverse events. New therapeutic approaches are currently developed to treat autoimmune diseases, mostly linked to the definition of new indications for biological agents such as TNF-alpha antagonists and rituximab.

Citation

C Schnider, J D Seebach, C Ribi, F Spertini. Systemic and neurological uses of immunosuppressive agents]. Revue médicale suisse. 2013 May 1;9(384):915-21