Endothelial function progressively deteriorates during normal pregnancy.

Kohei Fujita, Keiji Tatsumi, Eiji Kondoh, Yoshitsugu Chigusa, Haruta Mogami, Masatoshi Fujita, Ikuo Konishi

Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. gynef@kuhp.kyoto-u.ac.jp

Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy 2013 May

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To elucidate changes in endothelial function throughout the gestational period in normal pregnancy and its relationship with plasma soluble fms-like tyrosine kinase-1 (sFlt-1) levels. Endothelial function was evaluated by reactive hyperemia index (RHI) using Endo-PAT2000 and plasma sFlt-1 levels were measured simultaneously by ELISA. RHI gradually deteriorated with increasing gestational age. Plasma sFlt-1 levels exhibited a gradual increase at late pregnancy and were inversely correlated with RHI. Maternal endothelial function gradually deteriorates with increasing gestational age and there is an inverse correlation between endothelial function and plasma sFlt-1 levels in normal pregnancy.

Citation

Kohei Fujita, Keiji Tatsumi, Eiji Kondoh, Yoshitsugu Chigusa, Haruta Mogami, Masatoshi Fujita, Ikuo Konishi. Endothelial function progressively deteriorates during normal pregnancy. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy. 2013 May;32(2):129-38

PMID: 23725078

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