Targeting drug delivery systems for circumventing multidrug resistance of cancers.

Rui-Jun Ju, Li-Min Mu, Wan-Liang Lu

School of Pharmaceutical Sciences, Peking University, Beijing, China.

Therapeutic delivery 2013 Jun

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Multidrug resistance is a major obstacle to successful chemotherapy of cancer. To overcome multidrug resistance, our research is to develop new liposome and nanomicelle delivery systems. Investigations are focusing on certain aspects, including resistant cancer cell membranes, cancer stem cells, mitochondria, apoptosis genes, vasculogenic mimicry and heterogeneity of cancer cells. Evaluations have been performed on cancer cells, cancer spheroids and cancer animal models. These nanoscale formulations demonstrated an enhanced chemotherapy efficacy in resistant cancer and cancer stem cells in vitro and in vivo.

Citation

Rui-Jun Ju, Li-Min Mu, Wan-Liang Lu. Targeting drug delivery systems for circumventing multidrug resistance of cancers. Therapeutic delivery. 2013 Jun;4(6):667-71