PCR-based diagnosis of prosthetic joint infection.

We performed a meta-analysis to evaluate use of PCR assays for diagnosis of prosthetic joint infection (PJI). The pooled sensitivity and specificity were 0.86 (95% confidence interval [CI], 0.77 to 0.92) and 0.91 (CI, 0.81 to 0.96), respectively. Subgroup analyses showed that use of tissue samples may improve sensitivity, and quantitative PCR and sonication of prostheses fluid may improve specificity. The results showed that PCR is reliable and accurate for detection of PJI.

Citation

Xinhua Qu, Zanjing Zhai, Huiwu Li, Haowei Li, Xuqiang Liu, Zhenan Zhu, You Wang, Guangwang Liu, Kerong Dai. PCR-based diagnosis of prosthetic joint infection. Journal of clinical microbiology. 2013 Aug;51(8):2742-6

Mesh Tags

PMID: 23740731

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