Photoactivatable chemokines - controlling protein activity by light.
Lars Baumann, Annette G Beck-Sickinger
Universität Leipzig, Institute of Biochemistry, Brüderstrasse 34, 04103 Leipzig (Germany) http://www.biochemie.uni-leipzig.de/agbs/
Angewandte Chemie (International ed. in English) 2013 Sep 2Activation by light: Caged depsipeptides are incorporated as photoresponsive elements into the backbone of the protein SDF-1α by using expressed protein ligation. The disturbed secondary structure is restored after UV treatment by an O→N acyl rearrangement, and the chemotactic potential of the protein is regained. Nvoc=6-nitroveratryloxycarbonyl. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Citation
Lars Baumann, Annette G Beck-Sickinger. Photoactivatable chemokines - controlling protein activity by light. Angewandte Chemie (International ed. in English). 2013 Sep 2;52(36):9550-3
PMID: 23744757
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