Fixing a hole where the Ras gets in.

Jeffrey S Iwig, John Kuriyan

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell 2013 Jun 6

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A clinically efficacious Ras inhibitor has eluded drug-discovery efforts for decades. In a paper in Nature, Zimmermann and et al. show that blocking a hole in PDEδ that normally engages the lipid tail of Ras disrupts downstream signaling, pointing to a potentially promising route to develop Ras inhibitors for cancer treatment. Copyright © 2013 Elsevier Inc. All rights reserved.