Study of the relationship between shape and aggregation change in human erythrocytes].

The relationship between shape and spontaneous and fibrinogen-induced aggregation change in human erythrocytes was studied. Spontaneous and fibrinogen-induced erythrocyte aggregation was investigated using a rheoscope designed according to the method of H. Schmid-Schonbein et al. (1973). The erythrocyte shape was studied by means of light microscopy. It was shown that plasma enriched with lysophosphatidic acid and ATP depletion of erythrocytes led to the change of erythrocyte shape: discocytes transformed into echinocytes. It was found that spontaneous aggregation of such cells was considerably decreased. Aggregation of erythrocytes, treated with lysophosphatidic acid, was diminished more markedly. Fibrinogen-induced aggregation of echinocytes, obtained after treatment with lysophosphatidic acid and produced by ATP depletion, was also greatly reduced.

Citation

Iu A Sheremet'ev, A N Popovicheva, M N Egorikhina, G Ia Levin. Study of the relationship between shape and aggregation change in human erythrocytes]. Biofizika. 2013 Mar-Apr;58(2):264-8

Mesh Tags

Substances

PMID: 23755552

search → result