Adrenalectomy changes diazepam performance in male and female rats under multiparametric test conditions].

É A Manvelian, V A Baturin, N A Anisimova

Eksperimental'naia i klinicheskaia farmakologiia 2013

filter terms:

It is established that adrenalectomy decreases the "sedative" and "anti-anxiety" effects and reduces the "anxiogenic" effect of diazepam in male rats under multiparametric test conditions. At the same time, the "sedative" and "activating" effects of this tranquilizer do not appear in adrenalectomized female rats and the "anti-anxiety" effect is only observed in the evening. The "anxiogenic" effect of diazepam in females is not observed for a drug dose of 0.5 mg/kg and is only manifested at a dose of 0.1 mg/kg.

Citation

É A Manvelian, V A Baturin, N A Anisimova. Adrenalectomy changes diazepam performance in male and female rats under multiparametric test conditions]. Eksperimental'naia i klinicheskaia farmakologiia. 2013;76(4):7-10